Immunology
Team TMI
Translocation of Complex Macromolecules Across the Intestinal Epithelial Barrier
The main objective of the research group TMI was to discover novel transport mechanisms in the human intestinal tract which could be utilized for oral-systemic delivery of diverse therapeutic modalities (e.g., peptides, oligonucleotides, and antibodies). Studies involved screening of ligands, generating intestinal organoids from murine and human subjects, isolating intestinal cells, and creating a co-culture system. The project’s objectives were to develop a ligand specific for a target cell and establish quantitative assessment methods to monitor macromolecular drug delivery across the intestinal epithelial barrier. Our final goal was to create a novel delivery platform, which could be utilized for the development of a new generation of oral immunotherapies for the benefit of patients.
Publications
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- Gamero-Estevez, E., Hensel, I. V., Steinhauer, M., Müllertz, O., Savochkina, E., Sektioglu, I. M., Stoll, B., Derakhshani, S., Devriese, S., Kim, K. and Resnik-Docampo, M.(2025):
Protocol for Immune Cell Isolation, Organoid Generation, and Co-culture Establishment from Cryopreserved Whole Human Intestine
Bio-protocol 15(1)
- Gamero-Estevez, E., Hensel, I. V., Steinhauer, M., Müllertz, O., Savochkina, E., Sektioglu, I. M., Stoll, B., Derakhshani, S., Devriese, S., Kim, K. and Resnik-Docampo, M.(2025):
Team Location BioMed X Institute Heidelberg
The research of this team is kindly supported by Johnson & Johnson Innovative Medicine.
