Immunology
Team PTA
Protective Tissue Factors in Autoimmune Diseases
The main objective of the group is to understand the molecular mechanisms that promote pro-resolution responses in immune and stromal cells to restore homeostasis. In particular, the team will use the human synovium as a model system to characterize the pro-resolving phenotypes of macrophages in rheumatoid arthritis. The core of the project will be the development of a first in kind synovium-in-a-dish assay for systematic monitoring of macrophage functions. Our final goal is to identify new therapeutic targets, which promote pro-resolution in inflammation and autoimmune diseases, and thereby proposing novel concepts to improve patient outcomes.
Publications
- Edalat SG, Gerber R, Houtman M, Lückgen J, Teixeira RL, Palacios Cisneros MDP, Pfanner T, Kuret T, Ižanc N, Micheroli R, Polido-Pereira J, Saraiva F, Lingam S, Burki K, Burja B, Pauli C, Rotar Ž, Tomšič M, Čučnik S, Fonseca JE, Distler O, Calado Â, Romão VC, Ospelt C, Sodin-Semrl S, Robinson MD, Frank Bertoncelj M. Molecular maps of synovial cells in inflammatory arthritis using an optimized synovial tissue dissociation protocol. iScience. 2024 Apr 10;27(6):109707. doi: 10.1016/j.isci.2024.109707. PMID: 38832018; PMCID: PMC11144743. https://doi.org/10.1016/j.isci.2024.109707
Team Location BioMed X Institute Heidelberg
